Preheat your oven to 300°F (150°C) to prepare for baking the pretzels.
In a medium-sized bowl, combine garlic powder, onion powder, cayenne pepper, chili powder, paprika, and Takis seasoning. Mix well to create the seasoning blend.
Melt the butter in a separate bowl using the microwave or stovetop until fully liquid.
Place the party pretzels in a large mixing bowl. Pour the melted butter over the pretzels and toss gently but thoroughly to coat every pretzel.
Sprinkle the seasoning mix over the butter-coated pretzels and mix well using a spatula or clean hands for even distribution.
Spread the seasoned pretzels in a single layer on a baking sheet lined with parchment paper or a silicone baking mat.
Bake the pretzels in the preheated oven for about 15 minutes, stirring halfway through to prevent clumping and ensure even crisping.
Remove the pretzels from the oven and allow them to cool completely on the baking sheet to set the seasoning and achieve extra crunch.
Serve the Takis-Seasoned Party Pretzels as a snack on their own or with your favorite dips.