Bring a large pot of salted water to a boil. Add 8 ounces of penne pasta and cook according to package instructions until al dente, usually about 10-12 minutes. Drain the pasta and set aside, reserving about 1/4 cup of pasta water for later.
While the pasta is cooking, combine garlic powder, onion powder, smoked paprika, chipotle powder, salt, and pepper in a small bowl. Toss the bite-sized chicken pieces in olive oil, then sprinkle the seasoning mix over the chicken, ensuring each piece is coated evenly.
Heat a large skillet over medium-high heat. Add the seasoned chicken pieces and cook for 5-7 minutes, stirring occasionally, until the chicken is cooked through and golden brown on the outside. Remove from the skillet and set aside.
In the same skillet, reduce the heat to medium. Pour in 1 cup of ranch dressing and 1/2 cup of heavy cream. Stir well to combine, scraping up any browned bits from the bottom of the pan for extra flavor. Let the sauce simmer gently for 2-3 minutes until it thickens slightly.
Add the cooked chicken back to the skillet along with the drained penne pasta. Toss everything together, adding the 1/2 cup of grated Parmesan cheese and a splash of reserved pasta water if the sauce needs loosening. Stir until the cheese melts and the pasta is evenly coated with the creamy chipotle ranch sauce. Taste and adjust salt and pepper if needed.
Transfer the creamy chipotle ranch chicken pasta to serving plates or bowls. Sprinkle fresh chopped cilantro on top for a burst of color and fresh flavor. Serve immediately and enjoy!