Preheat your oven to 400°F (200°C). Line a baking sheet with parchment paper or a silicone mat to prevent sticking.
In a large mixing bowl, combine the all-purpose flour, granulated sugar, baking powder, and salt. Whisk together until evenly distributed.
Add the cold cubed unsalted butter to the flour mixture. Using a pastry cutter or fork, cut the butter into the dry ingredients until the mixture resembles coarse crumbs with pea-sized bits of butter still visible.
Stir in the dried cranberries and orange zest, ensuring they’re evenly dispersed throughout the flour and butter mixture.
In a separate bowl, whisk together the heavy cream, egg, and vanilla extract until smooth.
Pour the wet ingredients into the dry mixture. Gently fold with a spatula or wooden spoon until just combined. Be careful not to overmix, as this will make the scones tough.
Turn the dough out onto a lightly floured surface. Pat it into a 1-inch thick circle. Using a sharp knife or bench scraper, cut the dough into 8 equal wedges.
Place the scones onto the prepared baking sheet, spacing them about 2 inches apart. Bake for 18-22 minutes, or until the tops are golden brown and a toothpick inserted in the center comes out clean.
While the scones bake, whisk together the powdered sugar and orange juice in a small bowl until smooth.
Once the scones have cooled slightly but are still warm, drizzle the orange glaze over the top using a spoon. Let the glaze set for 10-15 minutes before serving.